Response of Motor Complications in Cockayne Syndrome to Carbidopa-Levodopa

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منابع مشابه

Response of motor complications in Cockayne syndrome to carbidopa-levodopa.

BACKGROUND Gait difficulties, tremors, and coordination difficulties are common features of Cockayne syndrome that are consequences of leukodystrophy, cerebellar atrophy, and demyelinating neuropathy, but no pharmacotherapy for these disabling symptoms is available. OBJECTIVE To determine whether carbidopa-levodopa relieves tremors and other motor complications of Cockayne syndrome. DESIGN ...

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Levodopa plus carbidopa before physiotherapy increased motor recovery after stroke.

Intervention Patients were allocated to levodopa, 100 mg, plus carbidopa (n=26) or to placebo (n=27) given daily in the morning > 30 minutes before the physiotherapy session for 3 weeks. For the next 3 weeks, both groups had 1 hour of daily physiotherapy from Monday to Friday without the allocated treatment. 1 week before and during the study, all patients stopped receiving any drugs that affec...

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Effects of levodopa/carbidopa intestinal gel versus oral levodopa/carbidopa on B vitamin levels and neuropathy

OBJECTIVES To determine the possible interactions between levodopa therapy and plasma levels of B vitamins in patients with advanced idiopathic Parkinson's disease (IPD) in the context of either oral levodopa therapy or levodopa/carbidopa intestinal gel (LCIG). Secondly, to determine the prevalence of neuropathy and its relation to plasma levels of B vitamins and homocysteine. METHODS Medicat...

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Levodopa/carbidopa for childhood amblyopia.

PURPOSE To evaluate the efficacy and tolerance of two low doses of levodopa/carbidopa (25/6.25 mg, 50/12.5 mg) and placebo (Tums) in 20 children with amblyopia between the ages of 4 and 14 years. METHODS A double-masked placebo-controlled randomized 8-hour study was performed during which subjects received one of two doses of levodopa/carbidopa or placebo, combined with occlusion of the domin...

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Levodopa-Carbidopa Intestinal Gel Pharmacokinetics: Lower Variability than Oral Levodopa-Carbidopa

In a double-blind, double-dummy, double-titration Phase 3 trial in advanced Parkinson's disease (PD) patients, the efficacy and safety of Levodopa-carbidopa intestinal gel (LCIG) infusion were characterized relative to immediate-release oral levodopa-carbidopa (LC-oral) treatment. We present in this report the comparative pharmacokinetic profiles of LCIG and LC-oral from this pivotal study. The...

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ژورنال

عنوان ژورنال: Archives of Neurology

سال: 2008

ISSN: 0003-9942

DOI: 10.1001/archneur.65.8.1117